Synthesis and Crystal Structure of 1-(3-Fluorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

Synthesis and Crystal Structure of 1-(3-Fluorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

The base catalyzed intramolecular nucleophilic cyclization of 1-(2-bromobenzoyl)-3-(2-fluorophenyl)thiourea (1) in the presence of N,N-dimethyl formamide (DMF) afforded the 1-(3-fluorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (2) by an intramolecular nucleophilic substitution SNAr mechanism....

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Bibliographic Details
Main Authors: Ulrich Flörke, Aamer Saeed
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Crystals
Subjects:
: quinazolinone
3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones
synthesis
Online Access:http://www.mdpi.com/2073-4352/1/4/254

Internet

http://www.mdpi.com/2073-4352/1/4/254

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