Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1α and NF-κB (p65)/Smad7 Pathways

Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1α and NF-κB (p65)/Smad7 Pathways

(1) Background: Astragaloside IV (AS-IV) is derived from Astragalus membranous (AM), which is used to treat kidney disease. Macrophages significantly affect the whole process of renal ischemia-reperfusion (I/R). The regulation of macrophage polarization in kidneys by AS-IV was the focus. (2) Methods...

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Bibliographic Details
Main Authors: Lumin Tang, Minyan Zhu, Xiajing Che, Xiaoqian Yang, Yao Xu, Qing Ma, Ming Zhang, Zhaohui Ni, Xinghua Shao, Shan Mou
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Journal of Personalized Medicine
Subjects:
Astragaloside IV
macrophage polarization
renal ischemia-reperfusion
renal fibrosis
NF-κB (p65)/Hif-1α
Hif-1α/Smad7
Online Access:https://www.mdpi.com/2075-4426/13/1/59

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https://www.mdpi.com/2075-4426/13/1/59

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