Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

Despite growing evidence suggesting that spinal microglia play an important role in the molecular mechanism underlying experimental neuropathic pain (NP) in male rodents, evidence regarding the sex-dependent role of these microglia in NP is insufficient. In this study, we evaluated the effects of mi...

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Bibliographic Details
Main Authors: Fumihiro Saika, Shinsuke Matsuzaki, Daichi Kobayashi, Yuya Ideguchi, Tomoe Y. Nakamura, Shiroh Kishioka, Norikazu Kiguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
allodynia
chronic pain
oxaliplatin
paclitaxel
spinal cord
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00925/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00925/full

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