Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches for increasing treatment effica...

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Bibliographic Details
Main Authors: Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
Mycobacterium tuberculosis
host-directed therapies
myeloid-derived suppressor cells
Sildenafil
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.883886/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.883886/full

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