Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells

Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells

Abstract Background The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new approach to improve their immunotherapeutic abilities. This strategy is associated with greater lactate release, and interestingly, recent studies have proposed l...

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Bibliographic Details
Main Authors: Carolina Pradenas, Noymar Luque-Campos, Karina Oyarce, Rafael Contreras-Lopez, Felipe A. Bustamante-Barrientos, Andrés Bustos, Felipe Galvez-Jiron, María Jesús Araya, Catalina Asencio, Raúl Lagos, Yeimi Herrera-Luna, Daouda Abba Moussa, Charlotte Nicole Hill, Eliana Lara-Barba, Claudia Altamirano, Alexander Ortloff, Yessia Hidalgo-Fadic, Ana María Vega-Letter, María de los Ángeles García-Robles, Farida Djouad, Patricia Luz-Crawford, Roberto Elizondo-Vega
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem/stromal cells
Glycolytic metabolism
Lactate dehydrogenase, lactate
Immunosuppression
Th1 and Th17 cells
Online Access:https://doi.org/10.1186/s13287-023-03549-4

Internet

https://doi.org/10.1186/s13287-023-03549-4

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