Optimization of miR-22 expression cassette for rAAV delivery on diabetes

Optimization of miR-22 expression cassette for rAAV delivery on diabetes

Abstract MicroRNA-22 (miR-22) was suggested to be important for type 2 diabetes but its functions for this disease remained unclear. Recombinant adeno-associated virus (rAAV)-mediated miR delivery is a powerful approach to study miR functions in vivo, however, the overexpression of miR-22 by rAAV re...

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Bibliographic Details
Main Authors: Li Yang, Wenya Du, Zhaoyue Zheng, Li Wang, Lin Xiao, Qingzhe Yang, Qiukui Hao, Jiao Zhou, Jintao Du, Jun Li, C. Alexander Valencia, Birong Dong, Hoi Yee Chow, Xianghui Fu, Biao Dong
Format: Article
Language:English
Published: Springer 2022-01-01
Series:Molecular Biomedicine
Subjects:
Recombinant adeno-associated virus
MicroRNA
Expression cassettes
MiR-22
Insulin
Online Access:https://doi.org/10.1186/s43556-021-00063-y

Internet

https://doi.org/10.1186/s43556-021-00063-y

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