Relevance of Fc Gamma Receptor Polymorphisms in Cancer Therapy With Monoclonal Antibodies
Therapeutic monoclonal antibodies (mAbs), including immune checkpoint inhibitors (ICIs), are an important breakthrough for the treatment of cancer and have dramatically changed clinical outcomes in a wide variety of tumours. However, clinical response varies among patients receiving mAb-based treatm...
Main Authors: | Juan J. Mata-Molanes, Joseba Rebollo-Liceaga, Elena Mª Martínez-Navarro, Ramón González Manzano, Antonio Brugarolas, Manel Juan, Manuel Sureda |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.926289/full |
Similar Items
-
Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
by: Christopher Beneduce, et al.
Published: (2023-08-01) -
Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors
by: Geoff Hale, et al.
Published: (2024-12-01) -
Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
by: Liming Liu
Published: (2017-04-01) -
Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro
by: Omar S. Qureshi, et al.
Published: (2024-12-01) -
Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry
by: Steffen Lippold, et al.
Published: (2021-01-01)