RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4

RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4

Abstract Background Gestational diabetes Mellitus (GDM) is a common pregnancy-specific disease with high morbidity, which is linked to a high risk of obesity and diabetes in offspring. N6-methyladenosine modification of RNA is emerging as an important epigenetic mechanism that is widely manifested i...

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Bibliographic Details
Main Authors: Jie Fang, Xiafei Wu, Jie He, Hanwen Zhang, Xuyang Chen, Hua Zhang, Boris Novakovic, Hongbo Qi, Xinyang Yu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Medicine
Subjects:
Gestational diabetes mellitus (GDM)
N6-methyladenosine (m6A)
Metabolic syndrome
RBM15
CLDN4
RNA modifications
Online Access:https://doi.org/10.1186/s10020-023-00615-8

Internet

https://doi.org/10.1186/s10020-023-00615-8

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