Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3)) is associated with a subtype of ADHD, but how it translates to symptoms is unknown. LPHN3 is a synap...

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Bibliographic Details
Main Authors: Samantha L. Regan, Jillian R. Hufgard, Emily M. Pitzer, Chiho Sugimoto, Yueh-Chiang Hu, Michael T. Williams, Charles V. Vorhees
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Latrophilin-3 (LPHN3 or ADGRL(3))
ADHD
Dopamine D1 receptor (DRD1)
Tyrosine hydroxylase
Aromatic amino acid decarboxylase (AADC)
DARPP-32
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301494

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http://www.sciencedirect.com/science/article/pii/S0969996119301494

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