Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells

Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells

Siglec-7 (sialic acid–binding immunoglobulin-like lectin 7) is an immune checkpoint-like glycan recognition protein on natural killer (NK) cells. Cancer cells often upregulate Siglec ligands to subvert immunosurveillance, but the molecular basis of Siglec ligands has been elusive. In this study, we...

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Bibliographic Details
Main Authors: Lan-Yi Chang, Suh-Yuen Liang, Shao-Chia Lu, Huan Chuan Tseng, Ho-Yang Tsai, Chin-Ju Tang, Marcelia Sugata, Yi-Ju Chen, Yu-Ju Chen, Shang-Ju Wu, Kuo-I Lin, Kay-Hooi Khoo, Takashi Angata
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
natural killer cells
Siglec-7
sialomucin
ST6GalNAc-IV
Core 2 GlcNAc transferase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.840388/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.840388/full

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