Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells

Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells

Background and Aims: Animal data show that the presence of an oncogenic Kras mutation in pancreatic acinar cells leads to acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasia (PanIN), and pancreatic ductal adenocarcinoma (PDAC). Inflammatory macrophages play an important role in t...

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Bibliographic Details
Main Authors: Soichiro Ako, Yaroslav Teper, Linda Ye, James Sinnett-Smith, Oscar J. Hines, Enrique Rozengurt, Guido Eibl
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Gastro Hep Advances
Subjects:
Pancreatic Cancer
Statins
Macrophages
Acinar-to-Ductal Metaplasia
Online Access:http://www.sciencedirect.com/science/article/pii/S2772572322000656

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http://www.sciencedirect.com/science/article/pii/S2772572322000656

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