High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease characterized by the presence of pathogenic autoantibodies, anti-aquaporin 4 (AQP4) antibodies. Recently, HLA-DQA1*05:03 was shown to be significantly associated with NMOSD in a Japanese patient cohort. However...

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Bibliographic Details
Main Authors: Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M. Standley, Tatsusada Okuno, Hideki Mochizuki
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-04074-1

Internet

https://doi.org/10.1038/s41598-021-04074-1

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