Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

Background PKARIα (protein kinase A type I‐α regulatory subunit) is redox‐active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARIα activation may be of relevance to cardiac excitation–contraction coupling. Methods and Results We used a r...

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Bibliographic Details
Main Authors: M. M. Towhidul Islam, Daniel Tarnowski, Min Zhang, Maximilian Trum, Simon Lebek, Julian Mustroph, Henriette Daniel, Johanna Moellencamp, Steffen Pabel, Samuel Sossalla, Ali El‐Armouche, Viacheslav O. Nikolaev, Ajay M. Shah, Philip Eaton, Lars S. Maier, Can Martin Sag, Stefan Wagner
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
heart failure
pressure overload
protein kinase A
redox
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.021985

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.021985

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