Cerebrospinal fluid-derived circulating tumor DNA is more comprehensive than plasma in NSCLC patients with leptomeningeal metastases regardless of extracranial evolution

Cerebrospinal fluid-derived circulating tumor DNA is more comprehensive than plasma in NSCLC patients with leptomeningeal metastases regardless of extracranial evolution

Introduction: Metastases to the central nervous system (CNS) are devastating neurological complications. Circulating cell-free tumor DNA (ctDNA) from cerebrospinal fluid (CSF) better represents genomic alterations in CNS tumors compared to plasma (PLA). However, the clinical value of cerebrospinal f...

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Bibliographic Details
Main Authors: Hainan Yang, Lei Wen, Chao Zhao, Jianing Chen, Zhaoming Zhou, Cheng Zhou, Linbo Cai, Caicun Zhou
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Cerebrospinal fluid
Next-generation sequencing
Brain metastases
Leptomeningeal metastases
Systemic disease progression
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022036623

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http://www.sciencedirect.com/science/article/pii/S2405844022036623

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