Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Abstract Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We d...

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Bibliographic Details
Main Authors: Ina Yoon, Sulhee Kim, Minjae Cho, Kyung Ah You, Jonghyeon Son, Caroline Lee, Ji Hun Suh, Da‐Jeong Bae, Jong Min Kim, Sinae Oh, Songhwa Park, Sanga Kim, Seong Hyeok Cho, Seonha Park, Kyuhyeon Bang, Minjeong Seo, Jong Hyun Kim, Bongyong Lee, Joon Seok Park, Kwang Yeon Hwang, Sunghoon Kim
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:EMBO Molecular Medicine
Subjects:
collagen
drug development
fibrosis
prolyl‐tRNA synthetase 1
Online Access:https://doi.org/10.15252/emmm.202216940

Internet

https://doi.org/10.15252/emmm.202216940

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