cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg.

We characterized the establishment of an Epidermal Growth Factor Receptor (EGFR) organizing center (EOC) during leg development in Drosophila melanogaster. Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each...

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Bibliographic Details
Main Authors: Susan Newcomb, Roumen Voutev, Aurelie Jory, Rebecca K Delker, Matthew Slattery, Richard S Mann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007568