Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence

Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence

BackgroundNK cells can be genetically engineered to express a transgenic T-cell receptor (TCR). This approach offers an alternative strategy to target heterogenous tumors, as NK:TCR cells can eradicate both tumor cells with high expression of HLA class I and antigen of interest or HLA class I negati...

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Bibliographic Details
Main Authors: Els P. van Hees, Laura T. Morton, Dennis F. G. Remst, Anne K. Wouters, Astrid Van den Eynde, J. H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
NK cells
T-cell receptor
cancer
multiple myeloma
Bob1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368290/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368290/full

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