Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.

The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells. XIAP is an inhibitor of apoptosis, mediating through its association with BIR3 domain of caspase 9. Embelin, a quinone derivative isolated from the Embe...

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Bibliographic Details
Main Authors: Kirti S Prabhu, Kodappully S Siveen, Shilpa Kuttikrishnan, Ahmad Iskandarani, Magdalini Tsakou, Iman W Achkar, Lubna Therachiyil, Roopesh Krishnankutty, Aijaz Parray, Michal Kulinski, Maysaloun Merhi, Said Dermime, Ramzi M Mohammad, Shahab Uddin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5509148?pdf=render

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http://europepmc.org/articles/PMC5509148?pdf=render

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