Modulation of Functional Phosphorylation Sites by Basic Residues in the Unique Domain of c-Src

Modulation of Functional Phosphorylation Sites by Basic Residues in the Unique Domain of c-Src

In contrast to the well-studied canonical regulatory mechanisms, the way by which the recently discovered Src N-terminal regulatory element (SNRE) modulates Src activity is not yet well understood. Phosphorylation of serine and threonine residues modulates the charge distribution along the disordere...

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Bibliographic Details
Main Authors: Andras Lang, Alejandro Fernández, Mireia Diaz-Lobo, Mar Vilanova, Francisco Cárdenas, Margarida Gairí, Miquel Pons
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
pKa measurements
phosphoserine
phosphothreonine
guanidinium–phosphate salt bridge
fuzzy complex
intrinsically disordered proteins
Online Access:https://www.mdpi.com/1420-3049/28/12/4686

Internet

https://www.mdpi.com/1420-3049/28/12/4686

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