Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of CFTR pore openings are coupled to tight dimerization of its two nucleotide-binding domains (NBDs) and...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/90736 |