Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of CFTR pore openings are coupled to tight dimerization of its two nucleotide-binding domains (NBDs) and...

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Bibliographic Details
Main Authors: Márton A Simon, Iordan Iordanov, Andras Szollosi, László Csanády
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
composite ATP-binding site
D-loop
zebrafish
flickery closure
mutant cycle
Online Access:https://elifesciences.org/articles/90736

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