WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

Abstract Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Zanthoxylum bungeanum Maxim, has anti-inflammatory...

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Bibliographic Details
Main Authors: Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei, Ke Cao
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
WGX50
DOX-induced cardiotoxicity
Mitochondrial ROS
GPX4
Ferroptosis
Online Access:https://doi.org/10.1186/s12967-023-04715-1

Internet

https://doi.org/10.1186/s12967-023-04715-1

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