Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae

Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae

The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous administration of PMB has many problems, such as severe neurotox...

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Bibliographic Details
Main Authors: Ziling Li, Huiling Lei, Jiannan Hu, Tong Zhou, Shuaiqi Yuan, Xinyue Ma, Yunfei Zhu, Chao Liu, Decai Wang, Yuzhou Wu, Shuyun Xu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
Subjects:
Klebsiella pneumoniae
Carbapenem resistance
Pneumonia
Nanoparticles
Pulmonary delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425001486

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http://www.sciencedirect.com/science/article/pii/S2590006425001486

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