Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published assays to date demanded a very high-depth sequenci...

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Main Authors: Van Thien Chi Nguyen, Trong Hieu Nguyen, Nhu Nhat Tan Doan, Thi Mong Quynh Pham, Giang Thi Huong Nguyen, Thanh Dat Nguyen, Thuy Thi Thu Tran, Duy Long Vo, Thanh Hai Phan, Thanh Xuan Jasmine, Van Chu Nguyen, Huu Thinh Nguyen, Trieu Vu Nguyen, Thi Hue Hanh Nguyen, Le Anh Khoa Huynh, Trung Hieu Tran, Quang Thong Dang, Thuy Nguyen Doan, Anh Minh Tran, Viet Hai Nguyen, Vu Tuan Anh Nguyen, Le Minh Quoc Ho, Quang Dat Tran, Thi Thu Thuy Pham, Tan Dat Ho, Bao Toan Nguyen, Thanh Nhan Vo Nguyen, Thanh Dang Nguyen, Dung Thai Bieu Phu, Boi Hoan Huu Phan, Thi Loan Vo, Thi Huong Thoang Nai, Thuy Trang Tran, My Hoang Truong, Ngan Chau Tran, Trung Kien Le, Thanh Huong Thi Tran, Minh Long Duong, Hoai Phuong Thi Bach, Van Vu Kim, The Anh Pham, Duc Huy Tran, Trinh Ngoc An Le, Truong Vinh Ngoc Pham, Minh Triet Le, Dac Ho Vo, Thi Minh Thu Tran, Minh Nguyen Nguyen, Thi Tuong Vi Van, Anh Nhu Nguyen, Thi Trang Tran, Vu Uyen Tran, Minh Phong Le, Thi Thanh Do, Thi Van Phan, Hong-Dang Luu Nguyen, Duy Sinh Nguyen, Van Thinh Cao, Thanh-Thuy Thi Do, Dinh Kiet Truong, Hung Sang Tang, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
liquid biopsy
multimodal analysis
circulating tumor DNA
Online Access:https://elifesciences.org/articles/89083

Internet

https://elifesciences.org/articles/89083

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