Normoxic HIF-1α Stabilization Caused by Local Inflammatory Factors and Its Consequences in Human Coronary Artery Endothelial Cells

Normoxic HIF-1α Stabilization Caused by Local Inflammatory Factors and Its Consequences in Human Coronary Artery Endothelial Cells

Knowledge about normoxic hypoxia-inducible factor (HIF)-1α stabilization is limited. We investigated normoxic HIF-1α stabilization and its consequences using live cell imaging, immunoblotting, Bio-Plex multiplex immunoassay, immunofluorescence staining, and barrier integrity assays. We demonstrate f...

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Bibliographic Details
Main Authors: Mohsen Abdi Sarabi, Alireza Shiri, Mahyar Aghapour, Charlotte Reichardt, Sabine Brandt, Peter R. Mertens, Senad Medunjanin, Dunja Bruder, Ruediger C. Braun-Dullaeus, Sönke Weinert
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
normoxic HIF-1α stabilization
coronary artery endothelial dysfunction
early atherosclerosis
micromilieu factors
Online Access:https://www.mdpi.com/2073-4409/11/23/3878

Internet

https://www.mdpi.com/2073-4409/11/23/3878

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