Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.

Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.

The ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with myristate. Arf proteins, including Arf1, have roles in membrane trafficking and cytoskel...

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Bibliographic Details
Main Authors: Eric M Rosenberg, Xiaoying Jian, Olivier Soubias, Rebekah A Jackson, Erin Gladu, Emily Andersen, Lothar Esser, Alexander J Sodt, Di Xia, R Andrew Byrd, Paul A Randazzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295103&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295103&type=printable

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