Multi-landmark alignment of genomic signals reveals conserved expression patterns across transcription start sites

Abstract The prevalent one-dimensional alignment of genomic signals to a reference landmark is a cornerstone of current methods to study transcription and its DNA-dependent processes but it is prone to mask potential relations among multiple DNA elements. We developed a systematic approach to align...

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Bibliographic Details
Main Authors: Jose M. G. Vilar, Leonor Saiz
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-37140-x