Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery

Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery

Intranasal administration offers an alternative and promising approach for direct nose-to-brain delivery. Herein, we developed two chitosan (CHT)-coated (and uncoated) nanoformulations of BNN27 (a synthetic C-17-spiro-dehydroepiandrosterone analogue), liposomes (LIPs), and nanoemulsions (NEs), and c...

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Bibliographic Details
Main Authors: Maria Kannavou, Kanelina Karali, Theodora Katsila, Eleni Siapi, Antonia Marazioti, Pavlos Klepetsanis, Theodora Calogeropoulou, Ioannis Charalampopoulos, Sophia G. Antimisiaris
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
BNN27
intranasal delivery
mucoadhesive formulations
chitosan
LIPs
nanoemulsions
Online Access:https://www.mdpi.com/1999-4923/15/2/419

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https://www.mdpi.com/1999-4923/15/2/419

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