Insight into Bortezomib Focusing on Its Efficacy against P-gp-Positive MDR Leukemia Cells

Insight into Bortezomib Focusing on Its Efficacy against P-gp-Positive MDR Leukemia Cells

In this paper, we compared the effects of bortezomib on L1210 (S) cells with its effects on P-glycoprotein (P-gp)-positive variant S cells, which expressed P-gp either after selection with vincristine (R cells) or after transfection with a human gene encoding P-gp (T cells). Bortezomib induced the d...

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Bibliographic Details
Main Authors: Tomáš Kyca, Lucia Pavlíková, Viera Boháčová, Anton Mišák, Alexandra Poturnayová, Albert Breier, Zdena Sulová, Mário Šereš
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
bortezomib
P-glycoprotein
L1210 cells
cyclin-dependent kinases
cyclins
CDK inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/11/5504

Internet

https://www.mdpi.com/1422-0067/22/11/5504

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