The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway

The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway

Purpose: The purpose of the present study was to estimate the effect of shionone (SHI) on sepsis-induced acute lung injury (ALI).Methods: The cecal ligation and puncture (CLP) surgery was performed to induce sepsis in mice. Pulmonary hematoxylin and eosin staining, the wet/dry ratio, myeloperoxidase...

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Bibliographic Details
Main Authors: Yi Song, Qian Wu, Huojun Jiang, Aihao Hu, Lingqi Xu, Caiping Tan, Biao Zhang, Rongming Yu, Yizhen Qiu, Xin Wang, Wenzhong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
shionone
sepsis-induced acute lung injury
macrophage polarization
ECM1/STAT5/NF-κB pathway
Aster tataricus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.764247/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.764247/full

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