Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins
Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, howev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1550 |
| _version_ | 1797487331887808512 |
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| author | Judit Oláh Tibor Szénási Attila Lehotzky Victor Norris Judit Ovádi |
| author_facet | Judit Oláh Tibor Szénási Attila Lehotzky Victor Norris Judit Ovádi |
| author_sort | Judit Oláh |
| collection | DOAJ |
| description | Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases. |
| first_indexed | 2024-03-09T23:47:06Z |
| format | Article |
| id | doaj.art-c447f9107e804ed688b32dd21efb411e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:06Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c447f9107e804ed688b32dd21efb411e2023-11-23T16:42:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233155010.3390/ijms23031550Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered ProteinsJudit Oláh0Tibor Szénási1Attila Lehotzky2Victor Norris3Judit Ovádi4Institute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, HungaryInstitute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, HungaryInstitute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, HungaryLaboratory of Microbiology Signals and Microenvironment, University of Rouen, 76821 Mont Saint Aignan, FranceInstitute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, HungaryProtein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases.https://www.mdpi.com/1422-0067/23/3/1550protein–protein interactiondrug targetdisordered proteinsneurodegeneration |
| spellingShingle | Judit Oláh Tibor Szénási Attila Lehotzky Victor Norris Judit Ovádi Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins International Journal of Molecular Sciences protein–protein interaction drug target disordered proteins neurodegeneration |
| title | Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins |
| title_full | Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins |
| title_fullStr | Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins |
| title_full_unstemmed | Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins |
| title_short | Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins |
| title_sort | challenges in discovering drugs that target the protein protein interactions of disordered proteins |
| topic | protein–protein interaction drug target disordered proteins neurodegeneration |
| url | https://www.mdpi.com/1422-0067/23/3/1550 |
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