L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells

L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells

Ferroptosis, an iron-dependent form of non-apoptotic cell death, plays important roles in cerebral ischemia. Previously we have found that L-F001, a novel fasudil-lipoic acid dimer with good pharmacokinetic characters has good neuroprotection against toxin-induced cell death in vitro and in vivo. He...

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Bibliographic Details
Main Authors: Weijia Peng, Ying Ouyang, Shuyi Wang, Jiawei Hou, Zeyu Zhu, Yang Yang, Ruiyu Zhou, Rongbiao Pi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
L-F001
ferroptosis
iron homeostasis
lipid peroxidation
c-Jun N-terminal kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.774297/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.774297/full

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