Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: A multicenter study from the AIDA Network PFAPA syndrome registry

Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: A multicenter study from the AIDA Network PFAPA syndrome registry

ObjectiveTo evaluate the potential role of Streptococcus salivarius K12 (SSK12) in controlling febrile flares in patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Further aims were to assess the impact of SSK12 on (i) flare duration, (ii) variati...

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Main Authors: Francesco La Torre, Jurgen Sota, Antonella Insalaco, Giovanni Conti, Emanuela Del Giudice, Riccardo Lubrano, Luciana Breda, Maria Cristina Maggio, Adele Civino, Violetta Mastrorilli, Roberta Loconte, Marco Francesco Natale, Camilla Celani, Mery Romeo, Serena Patroniti, Cristina Gentile, Antonio Vitale, Valeria Caggiano, Carla Gaggiano, Federico Diomeda, Marco Cattalini, Giuseppe Lopalco, Giacomo Emmi, Paola Parronchi, Stefano Gentileschi, Fabio Cardinale, Emma Aragona, Farhad Shahram, Achille Marino, Patrizia Barone, Carla Moscheo, Burcugul Ozkiziltas, Francesco Carubbi, Ohoud Alahmed, Ludovica Iezzi, Benson Ogunjimi, Angela Mauro, Maria Tarsia, Ayman Abdel-Monem Ahmed Mahmoud, Henrique Ayres Mayrink Giardini, Petros P. Sfikakis, Katerina Laskari, Ewa Więsik-Szewczyk, José Hernández-Rodríguez, Bruno Frediani, Verónica Gómez-Caverzaschi, Abdurrahman Tufan, Ibrahim A. Almaghlouth, Alberto Balistreri, Gaafar Ragab, Claudia Fabiani, Luca Cantarini, Donato Rigante
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Medicine
Subjects:
PFAPA syndrome
autoinflammatory disease
International Registry
Streptococcus salivarius K12
probiotic
tonsillitis
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1105605/full

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https://www.frontiersin.org/articles/10.3389/fmed.2023.1105605/full

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