Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons

In certain neurons from different brain regions, a brief burst of action potentials can activate a slow afterdepolarization (sADP) in the presence of muscarinic acetylcholine receptor agonists. The sADP, if suprathreshold, can contribute to persistent non-accommodating firing in some of these neuron...

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Bibliographic Details
Main Authors: Ya-Ting eLei, Sebastien J. Thuault, Pierre eLaunay, Robert eMargolskee, Eric R. Kandel, Steven A. Siegelbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
persistent firing
muscarinic receptors
slow afterdepolarization (sADP)
Ca2+-activated non-selective cation (CAN) current
transient receptor potential melastatin 5 channel (TRPM5)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00267/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00267/full

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