Development and comparison of 68Ga/18F/64Cu-labeled nanobody tracers probing Claudin18.2

Development and comparison of 68Ga/18F/64Cu-labeled nanobody tracers probing Claudin18.2

Claudin 18.2 (CLDN18.2) is an emerging target for the treatment of gastric cancers. We aim to develop tracers to image the expression of CLDN18.2. A humanized nanobody targeting CLDN18.2 (clone hu19V3) was produced and labeled with 68Ga, 64Cu, and 18F. The tracers were investigated in subcutaneous a...

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Bibliographic Details
Main Authors: Weijun Wei, Di Zhang, You Zhang, Lianghua Li, Yuchen Jin, Shuxian An, Chun lv, Haitao Zhao, Cheng Wang, Yanshan Huang, Jiali Dong, Gang Huang, Jianjun Liu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
Claudin 18.2
immunoPET
nanobody
radiopharmaceuticals
companion diagnostics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001383

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http://www.sciencedirect.com/science/article/pii/S2372770522001383

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