Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis

Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis

Conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA) by autotaxin, a secreted phospholipase D, is a major pathway for producing LPA. We previously reported that feeding Ldlr−/− mice standard mouse chow supplemented with unsaturated LPA or lysophosphatidylcholine qualitatively mimicke...

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Bibliographic Details
Main Authors: Arnab Chattopadhyay, Pallavi Mukherjee, Dawoud Sulaiman, Huan Wang, Victor Girjalva, Nasrin Dorreh, Jonathan P. Jacobs, Samuel Delk, Wouter H. Moolenaar, Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Lipid Research
Subjects:
lysophospholipase D
lysophosphatidic acid
atherosclerosis
oxidized phospholipids
small intestine
apolipoprotein A-I mimetic peptides
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000433

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http://www.sciencedirect.com/science/article/pii/S0022227523000433

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