Towards a molecular classification of colorectal cancer:The role of microsatellite instability status

Towards a molecular classification of colorectal cancer:The role of microsatellite instability status

Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair (MMR) deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests tha...

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Bibliographic Details
Main Author:	Karl eHeinimann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-10-01
Series:	Frontiers in Oncology
Subjects:	therapy colorectal cancer (CRC) mismatch repair (MMR) microsatellite instability (MSI) Lynch syndrome (LS) hereditary non-polyposis colon cancer (HNPCC)
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00272/full

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