Histone modifications are associated with transcript isoform diversity in normal and cancer cells.

Mechanisms that generate transcript diversity are of fundamental importance in eukaryotes. Although a large fraction of human protein-coding genes and lincRNAs produce more than one mRNA isoform each, the regulation of this phenomenon is still incompletely understood. Much progress has been made in...

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Bibliographic Details
Main Authors: Ondrej Podlaha, Subhajyoti De, Mithat Gonen, Franziska Michor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4046914?pdf=render