Caenorhabditis elegans SET1/COMPASS Maintains Germline Identity by Preventing Transcriptional Deregulation Across Generations

Caenorhabditis elegans SET1/COMPASS Maintains Germline Identity by Preventing Transcriptional Deregulation Across Generations

Chromatin regulators contribute to the maintenance of the germline transcriptional program. In the absence of SET-2, the Caenorhabditis elegans homolog of the SET1/COMPASS H3 Lys4 (H3K4) methyltransferase, animals show transgenerational loss of germline identity, leading to sterility. To identify tr...

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Bibliographic Details
Main Authors: Valérie J. Robert, Andrew K. Knutson, Andreas Rechtsteiner, Steven Garvis, Gaël Yvert, Susan Strome, Francesca Palladino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transgenerational
elegans
SET1
transcriptomics
cell identity
germline
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.561791/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.561791/full

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