The Membrane-Proximal Region of C–C Chemokine Receptor Type 5 Participates in the Infection of HIV-1

The Membrane-Proximal Region of C–C Chemokine Receptor Type 5 Participates in the Infection of HIV-1

The initial infection and transmission of HIV-1 requires C–C chemokine receptor type 5 (CCR5). Here, we report that the membrane-proximal region (MPR, aa 22–38) of CCR5 participates in the infection of HIV-1. First, MPR-specific antibodies elicited in mice dose-dependently inhibited the infection of...

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Bibliographic Details
Main Authors: Ying-Hua Chen, Ji Wang, Yue Tan, Pei Tong, Junyi Wang, Lei Zhao, Jing Li, Yang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
C–C chemokine receptor type 5
membrane-proximal region
HIV-1
blocking antibody
HIV vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00478/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00478/full

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