Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic analysis. Deep sequencing (1050–5000X; mean 1600X) w...

Full description

Bibliographic Details
Main Authors: Rozy Thakur, Prateek Bhatia, Minu Singh, Sreejesh Sreedharanunni, Pankaj Sharma, Aditya Singh, Amita Trehan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Diagnostics
Subjects:
B-ALL
deep sequencing
therapy-acquired
relapse
Online Access:https://www.mdpi.com/2075-4418/13/5/884

Internet

https://www.mdpi.com/2075-4418/13/5/884

Similar Items