A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

Abstract Background Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Survivin-responsive, conditionally replicating adenoviruses regulated by multiple tumor-specific factors (Surv.m-CRAs), in which the e...

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Bibliographic Details
Main Authors: Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi, Makoto Yoshimitsu, Naomichi Arima, Kenji Ishitsuka, Shin-ichi Ueno, Ken-ichiro Kosai
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
ATL
Survivin
Conditionally replicating adenoviruses
Online Access:http://link.springer.com/article/10.1186/s12885-019-5730-1

Internet

http://link.springer.com/article/10.1186/s12885-019-5730-1

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