Error estimates for the analysis of differential expression from RNA-seq count data

Background. A number of algorithms exist for analysing RNA-sequencing data to infer profiles of differential gene expression. Problems inherent in building algorithms around statistical models of over dispersed count data are formidable and frequently lead to non-uniform p-value distributions for nu...

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Bibliographic Details
Main Authors: Conrad J. Burden, Sumaira E. Qureshi, Susan R. Wilson
Format: Article
Language:English
Published: PeerJ Inc. 2014-09-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/576.pdf