MCProj: metacell projection for interpretable and quantitative use of transcriptional atlases
Abstract We describe MCProj—an algorithm for analyzing query scRNA-seq data by projections over reference single-cell atlases. We represent the reference as a manifold of annotated metacell gene expression distributions. We then interpret query metacells as mixtures of atlas distributions while corr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-023-03069-7 |