Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity

Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity

Summary: Nucleic acid-binding polymers can have anti-inflammatory properties and beneficial effects in animal models of infection, trauma, cancer, and autoimmunity. PAMAM G3, a polyamidoamine dendrimer, is fully cationic bearing 32 protonable surface amines. However, while PAMAM G3 treatment leads t...

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Bibliographic Details
Main Authors: Lyra B. Olson, Nicole I. Hunter, Rachel E. Rempel, Haixiang Yu, Diane M. Spencer, Cynthia Z. Sullenger, William S. Greene, Anastasia K. Varanko, Seyed A. Eghtesadi, Ashutosh Chilkoti, David S. Pisetsky, Jeffrey I. Everitt, Bruce A. Sullenger
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Immunology
Biomolecular engineering
Nanotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222018144

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222018144

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