ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway

Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in...

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Bibliographic Details
Main Authors: Xin Wen, Si Chen, Xueting Chen, Hui Qiu, Wei Wang, Nie Zhang, Wanming Liu, Tingting Wang, Xin Ding, Longzhen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
pancreatic adenocarcinoma (PAAD)
ITGB5
radio-sensitivity
MEK/ERK signaling pathway
DNA damage repair
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.887068/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.887068/full

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