Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Abstract Elderly people and patients with comorbidities are at higher risk of COVID-19 infection, resulting in severe complications and high mortality. However, the underlying mechanisms are unclear. In this study, we investigate whether miRNAs in serum exosomes can exert antiviral functions and aff...

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Bibliographic Details
Main Authors: Yanbo Wang, Xiaoju Zhu, Xia-Ming Jiang, Jingwei Guo, Zheng Fu, Zhen Zhou, Ping Yang, Hongyuan Guo, Xu Guo, Gaoli Liang, Ping Zeng, Gengfu Xiao, Jizheng Ma, Xin Yin, Lei-Ke Zhang, Chao Yan, Chen-Yu Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00716-y

Internet

https://doi.org/10.1038/s41392-021-00716-y

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