New roles for autophagy and spermidine in T cells
The conserved lysosomal degradation pathway autophagy is now recognised as an essential cog in immune function. While functionally widespread in the innate immune system, knowledge of its roles in adaptive immunity is more limited. Although autophagy has been implicated in naïve T cell homeostasis,...
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Format: | Article |
Language: | English |
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Shared Science Publishers OG
2015-03-01
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Series: | Microbial Cell |
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Online Access: | http://microbialcell.com/researcharticles/new-roles-for-autophagy-and-spermidine-in-t-cells/ |
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author | D. J. Puleston A. K. Simon |
author_facet | D. J. Puleston A. K. Simon |
author_sort | D. J. Puleston |
collection | DOAJ |
description | The conserved lysosomal degradation pathway autophagy is now recognised as an essential cog in immune function. While functionally widespread in the innate immune system, knowledge of its roles in adaptive immunity is more limited. Although autophagy has been implicated in naïve T cell homeostasis, its requirement in antigen-specific T cells during infection was unknown. Using a murine model where the essential autophagy gene Atg7 is deleted in the T cell lineage, we have shown that autophagy is dispensable for effector CD8+ T cell responses, but crucial for the formation of memory CD8+ T cells. Here, we suggest reasons why autophagy might be important for the formation of long-lasting immunity. Like in the absence of autophagy, T cell memory formation during ageing is also defective. We observed diminished autophagy levels in T cells from aged mice, linking autophagy to immunosenescence. Importantly, T cell responses to influenza vaccination could be significantly improved using the autophagy-inducing compound spermidine. These results suggest the autophagy pathway as a desirable target to improve aged immunity and modulate T cell function. |
first_indexed | 2024-04-13T09:20:17Z |
format | Article |
id | doaj.art-c4861579c8e649beace32643bd3a4cf7 |
institution | Directory Open Access Journal |
issn | 2311-2638 |
language | English |
last_indexed | 2024-04-13T09:20:17Z |
publishDate | 2015-03-01 |
publisher | Shared Science Publishers OG |
record_format | Article |
series | Microbial Cell |
spelling | doaj.art-c4861579c8e649beace32643bd3a4cf72022-12-22T02:52:37ZengShared Science Publishers OGMicrobial Cell2311-26382015-03-0123919310.15698/mic2015.03.195New roles for autophagy and spermidine in T cellsD. J. Puleston0A. K. Simon1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS.MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS.The conserved lysosomal degradation pathway autophagy is now recognised as an essential cog in immune function. While functionally widespread in the innate immune system, knowledge of its roles in adaptive immunity is more limited. Although autophagy has been implicated in naïve T cell homeostasis, its requirement in antigen-specific T cells during infection was unknown. Using a murine model where the essential autophagy gene Atg7 is deleted in the T cell lineage, we have shown that autophagy is dispensable for effector CD8+ T cell responses, but crucial for the formation of memory CD8+ T cells. Here, we suggest reasons why autophagy might be important for the formation of long-lasting immunity. Like in the absence of autophagy, T cell memory formation during ageing is also defective. We observed diminished autophagy levels in T cells from aged mice, linking autophagy to immunosenescence. Importantly, T cell responses to influenza vaccination could be significantly improved using the autophagy-inducing compound spermidine. These results suggest the autophagy pathway as a desirable target to improve aged immunity and modulate T cell function.http://microbialcell.com/researcharticles/new-roles-for-autophagy-and-spermidine-in-t-cells/autophagyT cell memoryspermidineT cellsageingimmunosenescenceimmunity |
spellingShingle | D. J. Puleston A. K. Simon New roles for autophagy and spermidine in T cells Microbial Cell autophagy T cell memory spermidine T cells ageing immunosenescence immunity |
title | New roles for autophagy and spermidine in T cells |
title_full | New roles for autophagy and spermidine in T cells |
title_fullStr | New roles for autophagy and spermidine in T cells |
title_full_unstemmed | New roles for autophagy and spermidine in T cells |
title_short | New roles for autophagy and spermidine in T cells |
title_sort | new roles for autophagy and spermidine in t cells |
topic | autophagy T cell memory spermidine T cells ageing immunosenescence immunity |
url | http://microbialcell.com/researcharticles/new-roles-for-autophagy-and-spermidine-in-t-cells/ |
work_keys_str_mv | AT djpuleston newrolesforautophagyandspermidineintcells AT aksimon newrolesforautophagyandspermidineintcells |