A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin

A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin

Diet-related lipotoxic stress is a significant driver of skeletal muscle insulin resistance (IR) and type 2 diabetes (T2D) onset. β<sub>2</sub>-adrenergic receptor (β-AR) agonism promotes insulin sensitivity in vivo under lipotoxic stress conditions. Here, we established an in vitro para...

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Bibliographic Details
Main Authors: Jinhee Hwang, Rekha Balakrishnan, Eunjin Oh, Rajakrishnan Veluthakal, Debbie C. Thurmond
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
DOC2B
β-adrenergic receptor
insulin resistance
skeletal muscle
GLUT4
glucose uptake
Online Access:https://www.mdpi.com/1422-0067/25/1/137

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https://www.mdpi.com/1422-0067/25/1/137

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