BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells.

BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells.

PTEN loss and constitutive activation of the PI3K signaling pathway have been associated with advanced androgen-independent prostate cancer. PTEN-deficient prostate cancer C42Luc cells survive in serum-free media and show relative resistance to apoptosis even in the presence of the PI3K inhibitor ZS...

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Bibliographic Details
Main Authors: Dana Yancey, Kyle C Nelson, Daniele Baiz, Sazzad Hassan, Anabel Flores, Ashok Pullikuth, Yelena Karpova, Linara Axanova, Victoria Moore, Guangchao Sui, George Kulik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3764099?pdf=render

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http://europepmc.org/articles/PMC3764099?pdf=render

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